The divergence of major histocompatibility complex class I genes in Sciurus aberti

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The divergence of major histocompatibility complex class I genes in Sciurus aberti.

Major histocompatibility complex (MHC) class I genes encode cell surface molecules that bind and present immunogenic peptides to cytolytic T lymphocytes. We have developed a model using the MHC (Scab) of tassel-eared squirrels, Sciurus aberti, to investigate the evolution of MHC genes in subspecies that have been effectively isolated in comparable, if not identical, environments. Class I cDNAs ...

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Major Histocompatibility Complex, Class I, B

Description The genes of the Human Leukocyte Antigen (HLA) system reside on chromosome 6, and code for cellsurface proteins that play a crucial role in the presentation of endogenic peptides to effector cells of the immune system. The HLA Class I protein molecule is a heterodimer, made up of two chains; a heavy one and a light one (beta 2 microglobulin). The HLA-B gene is one of the three HLA C...

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ژورنال

عنوان ژورنال: Molecular Biology and Evolution

سال: 1996

ISSN: 0737-4038,1537-1719

DOI: 10.1093/oxfordjournals.molbev.a025570